Alzheimer Disease

Disease State Hub

Clinical Insights

Memory

Developing Treatments for Alzheimer Disease Is Challenging

07/28/2016

Stevin Zorn, PhD, discusses research into exploitation of a single mechanism of action for possible treatment and prevention of Alzheimer disease, and a possible shift of focus towards experimenting with...

07/28/2016

Genetics

Alison Goate, DPhil, on the Genetics of Alzheimer Disease

09/18/2015

Alison Goate, DPhil, answered our questions about her research on the role of genetics in Alzheimer disease onset, a topic she will also be presenting at 144th Annual Meeting of the American Neurological...

09/18/2015

conference coverage

Agitation in Alzheimer’s Dementia: Progress for an Age-Old Problem

05/25/2015

In this video, Craig Chepke, MD, DFAPA, and Kevin Williams, MS, MPAS, PA-C Provide the take-home messages from their session “Agitation in Alzheimer’s Dementia: Progress for an Age-Old Problem” at our...

05/25/2015

For more on the etiology of Alzheimer disease content, visit our Clinical Update page

The most common type of dementia, Alzheimer disease is a progressive disease that generally begins with mild memory loss and involves parts of the brain that control thought, memory, and language.

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Brain changes may begin 10+ years before symptoms appear. These changes include buildup of proteins that form amyloid plaques and tau tangles. This causes healthy neurons to stop functioning, lose connections with other neurons, and die.

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occupational therapist, neurologist, geriatrician, psychiatrist, primary care physicians, geropsychologist

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Memory loss that disrupts daily life
Difficulty completing familiar tasks at home, at work, or at leisure
Worsening judgment
Misplacing items & failure to retrace steps
Changes in mood, personality, or behavior

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There is no single test to determine AD, but testing options include: computed tomography scan, magnetic resonance imaging, positron emission tomography scan, cerebrospinal fluid analysis, neurological examination

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Examples of cognitive, functional, and behavioral tests include: Ascertain Dementia 8, Activities Questionnaire, Mini-Cog Mini-Mental State Examination, Montreal Cognitive Assessment, Neuropsychiatric Inventory Questionnaire

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Age
Family history
Genetics
Mild cognitive impairment
Modifiable risk factors, like obesity, high cholesterol, poorly controlled type 2 diabetes

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An estimated 6.7 million Americans aged 65 years or older are living with AD (73% are aged 75 years or older)

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By 2025, the number of people aged 65 or older with AD is projected to reach 7.2 million — a 7% increase from 2023.

November 2024

Current Issue

November 2024

Sources

CDC.gov
2023 Alzheimer's Facts and Figures