HIV Disrupts Metabolic Health in Non-Obese Men
Human immunodeficiency virus (HIV) infection is associated with lower metabolic health prevalence among non-obese men, according to a recent study.
Previous evidence has shown that HIV and antiretroviral therapy are associated with metabolic disturbances. However, less is currently known about how body mass index (BMI) affects this association.
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In the multicenter AIDS cohort study, researchers performed a cross-sectional analysis of HIV-positive (n = 1018) and HIV-negative (n = 1092) men. Mean patient age was 54 years in HIV-positive men and 59 years in HIV-negative men.
Associations between HIV serostatus and metabolic health prevalence were explored via Poisson regression with robust variance. Metabolic health prevalence was defined as meeting at least 2 of 5 National Cholesterol Education Program Adult Treatment Panel III metabolic syndrome criteria.
Results of the adjusted model demonstrated that non-obese HIV-positive men had a reduced likelihood of metabolic health compared with their non-obese HIV-negative counterparts (BMI of 25 kg/m2 or less, 80% vs 94%; BMI of 25-29 kg/m2, 64% vs 71%). However, no association between metabolic health prevalence HIV serostatus was observed among obese men.
The researchers noted that among HIV-positive men, per-year use of darunavir, zidovudine, and stavudine was associated with a lower likelihood of metabolic health.
“Metabolically healthy obesity prevalence does not differ by HIV serostatus,” the researchers concluded. “However, among non-obese men, HIV infection is associated with lower metabolic health prevalence, with associations between lack of metabolic health and darunavir and thymidine analog nucleoside reverse transcriptase inhibitor exposure observed.”
—Christina Vogt
Reference:
Lake JE, Li X, Palella FJ, et al. Metabolic health across the BMI spectrum in HIV-infected and HIV-uninfected men. AIDS. 2018;32(1):49-57. doi:10.1097/QAD.0000000000001651.