Which Antioxidants Can Improve Vascular Function in HFpEF?

A combination of over-the-counter antioxidants may improve vascular function among individuals with heart failure with preserved ejection fraction (HFpEF), according to new research presented at the American Physiological Society’s annual meeting.

To reach this conclusion, the researchers conducted a double-blind study of 16 participants with HFpEF. The participants were sequentially given either a placebo or a combination of alpha lipoic acid, 600mg; vitamin C, 1000 mg; and vitamin E, 600IU.

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Markers of vascular function, inflammation, and oxidative stress were measured for each participant. 

While there were no changes in either small blood vessel function or oxidative stress, large blood vessel function and inflammation had improved. The presence of biologically available nitric oxide had also increased during the study period.

“[The findings provide] new insight into the mechanisms that govern peripheral vascular dysfunction [in individuals with HFpEF],” the researchers concluded, who say the findings suggest that that antioxidant administration may represent a simple and readily available option to improve vascular health among individuals with HFpEF.

—Colleen Murphy

Reference:

Over-the-counter antioxidant cocktail improved vascular function in certain patients with heart failure [press release]. Orlando, FL: American Physiological Society; April 7, 2019. http://www.the-aps.org/mm/hp/Audiences/Public-Press/2019-22.html. Accessed April 9, 2019.