Psoriatic Arthritis Increases the Risk for Uveitis, Crohn Disease

Individuals with psoriatic arthritis have a higher risk for uveitis and Crohn disease than the general population and individuals with psoriasis, according to a new review.

To conduct their study, the researchers used data from the UK Clinical Practice Research Datalink between 1998 and 2014. Individuals with psoriatic arthritis who were aged 18 to 89 years were included in the study analysis (N = 6783).

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Participants with psoriatic arthritis were matched to individuals with psoriasis and a member of the general population.

Poisson regression was used to determine the adjusted relative risks of uveitis, IBD, Crohn disease, and ulcerative colitis.

Results showed that participants with psoriatic arthritis had a higher risk of uveitis than the general population and psoriasis cohorts. Psoriatic arthritis also significantly increased the risk for Crohn disease but not for ulcerative colitis.

“In a primary care-based incidence cohort of patients with [psoriatic arthritis], there were substantial risks of developing uveitis and/or Crohn’s disease, but not ulcerative colitis, when compared with the general population and psoriasis controls,” the researchers concluded.

—Amanda Balbi

Reference:

Charlton R, Green A, Shaddick G, et al; PROMPT study group. Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population-based cohort study. Ann Rheumat Dis. 2018;77:277-280.